MUSC Welcome

Opportunities in Translational Research

Integration of the Basic and Clinical Sciences to Provide Training in
Translational Research

The NIH and Congress have been concerned that the graduates of M.D./Ph.D. programs have not been conducting translational research. We contend that one of the reasons that M.D./Ph.D. students have not conducted clinical investigation (translational research) is that they have been only trained to conduct bench research and, therefore, when they complete all their training, they naturally continue their basic science research. In response to these concerns and keeping with the philosophy of the program which is to rigorously train M.D./Ph.D. students the program has a series of programs available to its students that will allow them to receive training in clinical investigation, while still learning the rigors of hypothesis driven research. Below are listed opportunities that our program provides for its trainees to gain a better experience in translational research.

As part of the NIH roadmap initiative a major emphasis has been placed on clinical and translational research. The Medical University of South Carolina is committed to the concept of developing an enhanced infrastructure to facilitate clinical and translational research.

1. Medical Scientist Training Program Clinic in Translational Sciences

Course # MDCOR-871
Course Co-Directors:
Perry V. Halushka, Ph.D., M.D. Program Director, MSTP
Robin Muise-Helmericks, Ph.D. Associate Program Director, MSTP

Duration: 15 weeks (one 1/2 day per week)
Credit hours: 2.5 per semester.

The goal of this clinic is for MSTP students to learn how to better integrate the basic sciences and their area of research interest with a meaningful clinical/translational experience. The clinic is conducted during the student's Ph.D. training. The students are expected to discuss the patient's problems from a literature/research perspective. They work in a clinic, one-half day a week with an extramurally funded clinician-scientist who is chosen based on his/her demonstrated commitment to research. This translational clinical experience is required of MSTP students. The mentors for this clinic could help the students with a potential clinical study that may evolve from their basic science project. The course plan for the Clinic in Translational Sciences follows:


  • Create an environment where students begin to develop an appreciation for the process of translational research
  • Introduce students to mentors who can serve as role models


  • Requires prior approval from dissertation advisor and graduate program coordinator
  • Students attend clinic no more than one half-day a week and with the same faculty mentor
  • One semester blocks
  • Program is pass/fail/honors
  • One semester may be used to satisfy two weeks required for a clinical elective in the senior year of medical school

Choosing a Mentor:

  • A list of mentors who are clinician-scientists is provided and approved by the Associate Program Director and/or Program Director
  • Whenever possible and/or appropriate the students will choose a mentor/clinic that is related to their dissertation research

Schedule with Mentor:

  • Introductory period to gain familiarity with the clinic
  • Mentor assigns patient(s)
  • Students will evaluate no more than one new patient per clinic and will see their return patients
  • Students are responsible for patient care (history, physical examinations, diagnosis and treatment plan) while the patient is under the care of that clinic

Clinical Research:

  • Students will research the latest concepts concerning the patient's disease and discuss them with the clinician-scientist

Expectations of Students:

  • Demonstrate a detailed understanding of the pathophysiology and treatment of the disease
  • Provide support for diagnosis and treatment that they propose
  • Demonstrate knowledge of current literature and provide references
  • Acquire proficiency in the history and physical examination

Expectations of Mentors:

  • Constructively challenge student's knowledge of current research literature
  • Practice evidence based medicine
  • Help the student gain skills in the history, physical examination, differential diagnosis and treatment

Evaluation of the MSTP clinic in translational sciences:

  • Both students and mentors are required to fill out an evaluation form at the end of each semester

2. Rotation in the SCTR Research Nexus

The SCTR Research Nexus

Course # MED-832
Course Co-Directors:
Dr. Carol Wagner and Dr. Thomas C. Hulsey

During the senior year of medical school, MSTP students spend a month in the General Clinical Research Center. The center is the hub of clinical investigation. The time is spent in a series of experiences that provide a significant exposure to clinical/translational research. Students spend time working with clinical researchers, attend Institutional Review Board meetings, attend SCTR Research Nexus advisory committee meetings, attend lectures about clinical research topics and meet with the support personnel for the SCTR Research Nexus. The major objective is for the student to write a clinical protocol based on the discoveries made during the basic science research that he/she conducted during the PhD years. Alternatively, students may design a protocol based on their future career path. A full protocol is developed along with an informed consent. The student works with a mentor and obtains all the help necessary to fully develop the clinical study. At the end of the course the student formally presents his/her protocol to members of the SCTR Research Nexus and selected other individuals. While this experience per se will not make the student an accomplished clinical investigator, it will break down some of the myths and barriers real or perceived that have impeded MD/PhD students from conducting clinical translational research.



  • Students will develop an understanding of and foundation in the principles of Clinical Investigation


Students will:

  • Participate in the protocols being conducted in the SCTR Research Nexus
  • Attend the SCTR Research Nexus advisory committee meeting
  • Attend an IRB meeting
  • Develop a clinical investigation protocol based on their dissertation research or future career path and present it for approval
  • Participate in the Controversies in Medicine Seminar Series
  • Learn statistical approaches used in clinical investigation